Flexible approach
We offer a wide range of peptide modifications
Our team has experience in synthesizing high-quality peptides with diverse modifications. With extensive equipment, we can deliver peptides in both small (mg) and large (kg) scales, in a short time.
Modifications
N-TERM
- Acetylation (Ac)
- Formylation (For)
- Fatty acid addition
- Benzoyl (Bz)
- Benzyloxycarbonylation (CBZ)
- Bromoacetylation (Br-Ac)
- Pyroglutamyl (pGlu) (Pyr)
- Succinylation (Suc)
- Tert-butoxycarbonyl (Boc)
- 3-Mercaptopropyl (Mpa)
Modifications
C-TERM
- Amidation
- AMC
- Aldehyde (new)
- Alcohol (new)
- Esters (OMe, OEt) (new)
- p-Nitroaniline (pNA)
- NHMe, NHEt and Nhisopen
- tBu
- TBzl
- Cysteamine (Cya)
Modifications
Other modifications
- Biotin and FITC labeling
- Disulfide bridges
- Phosphorylation
- Conjugation with BSA, KLH, OVA
- PEGylation
- MAPS (Multiple Antigen Peptide System)
- Cyclic peptides
- Fluorescent quenched peptides
- Special amino acids
- Methylation and N-methylation
Knowledge Base
Explore selected modifications
Discover the most commonly used peptide modifications that influence their stability, biological activity, and application possibilities. We offer a wide range of modifications — from simple changes to peptide termini to advanced labeling and cyclization — tailored to your research requirements.
Amidation and acetylation
If a peptide originates from an internal protein sequence, C-terminal amidation (–CONH₂) or N-terminal acetylation allows for charge removal, making it more similar to the natural structure.
Biotin and FITC
FITC labeling is performed at the N-terminus using an active fluorescein precursor. For efficiency, a six-carbon linker is used between the fluorophore and the N-terminus.
Disulfide bridges
Cyclic peptides can be formed via disulfide bridges between cysteine residues. For peptides with multiple cysteines, the process requires precise design.
Phosphorylation
Phosphopeptides are crucial for studying the impact of phosphorylation on protein structure and regulation. Novazym synthesizes phosphorylated peptides on serine, threonine, and tyrosine...
Methylation
Protein methylation plays an important role in regulating cellular processes such as transcription and cell differentiation. Novazym synthesizes peptides containing...
Conjugation with carrier proteins
Small peptides are weakly immunogenic, so they are often conjugated with large carrier proteins, such as BSA, OVA, or KLH. Conjugation is performed using the maleimide method, by adding cysteine...
Isotopic labeling
For NMR studies, stable isotopes (²H, ¹⁵N, ¹³C) can be incorporated. Labeled peptides can be individually customized for the research project...
MAPS – Multiple Antigen Peptide System
The multiple antigen peptide system is based on using lysine residues as a scaffold to which multiple peptide chains are attached...
PEGylation
Involves the covalent conjugation of peptides or other macromolecules with polyethylene glycol (PEG). This increases solubility, bioavailability, circulation time in the body...
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